The Benefits of Low-Dose Naltrexone (LDN): A Game-Changer for Autoimmune Diseases and Overall Health

We're thrilled to feature a guest blog post from the esteemed Dr. Ruthie Harper M.D., a renowned functional medicine practitioner here in Austin. In this informative piece, Dr. Harper delves into the world of Low-Dose Naltrexone (LDN), a unique compounded medication that our pharmacy specializes in.
LDN has shown promise in addressing a range of conditions, including autoimmune diseases, chronic pain, anxiety, PCOS, and even supporting overall well-being. Dr. Harper provides valuable insights into how LDN works and its potential benefits. Other conditions that have shown improvement with Low-Dose Naltrexone therapy includes:
- • LDN for Fibromyalgia
- • LDN for Chronic Fatigue Syndrome
- • LDN for Multiple Sclerosis
- • LDN for Autoimmune Diseases
- • LDN for Crohn's Disease
- • LDN for Irritable Bowel Syndrome
- • LDN for Pain Management
Low-Dose Naltrexone (LDN) has emerged as a promising therapeutic option for a wide range of health conditions, particularly autoimmune diseases. Originally approved by the FDA in 1984 for treating opioid addiction at standard doses, naltrexone is now making waves in the medical community for its off-label use at much lower doses (typically 1.5–4.5 mg). LDN is unique in its wide-ranging benefits, from calming autoimmunity to improving general health.
How Does Low-Dose Naltrexone Work?
At low doses, naltrexone acts differently than it does at standard doses. It temporarily blocks opioid receptors in the brain, which triggers a rebound effect, causing the body to increase its production of endorphins and enkephalins—natural chemicals that reduce pain, regulate the immune system, and promote healing.
This unique mechanism makes LDN particularly effective for managing autoimmune diseases and other chronic conditions.
LDN for Autoimmune Diseases


Autoimmune diseases occur when the immune system mistakenly attacks the body’s own tissues. LDN helps modulate the immune system, restoring balance without suppressing its natural function. Here are some specific autoimmune conditions where LDN has shown benefits:
1. Multiple Sclerosis (MS):
Studies suggest that LDN can reduce fatigue, improve mobility, and alleviate pain in individuals with MS. Its immune-modulating effects may slow disease progression.
2. Rheumatoid Arthritis (RA):
LDN reduces inflammation and joint pain, improving overall quality of life for RA patients. Unlike traditional treatments, LDN carries a lower risk of side effects.
3. Hashimoto’s Thyroiditis:
By modulating the immune system, LDN may reduce thyroid antibodies and improve symptoms like fatigue and brain fog. Many patients report better energy levels and improved thyroid function.
4. Crohn’s Disease and Ulcerative Colitis:
Research has demonstrated that LDN can help reduce intestinal inflammation and promote mucosal healing in inflammatory bowel diseases (IBD). Patients often experience fewer flare-ups and better symptom control.
Other Health Benefits of LDN


LDN’s versatility extends beyond autoimmune conditions. It offers a range of health benefits, making it a valuable tool in functional medicine:
1. Chronic Pain Relief:
LDN is effective in reducing chronic pain conditions like fibromyalgia, complex regional pain syndrome (CRPS), and chronic fatigue syndrome (CFS). By increasing endorphins, it enhances the body’s natural pain relief mechanisms.
2. Mental Health Support:
Patients with depression or anxiety may benefit from LDN due to its ability to boost endorphins and regulate mood. It has also been explored for its neuroprotective effects in conditions like Alzheimer’s disease and Parkinson’s disease.
3. Cancer Support:
Preliminary studies suggest that LDN may help slow tumor growth by enhancing the immune system's ability to detect and attack cancer cells. It may also alleviate pain and improve quality of life in cancer patients.
4. Skin Conditions:
Conditions like eczema, psoriasis, and lichen planus may improve with LDN, as it reduces inflammation and regulates immune activity.
5. Metabolic and Hormonal Balance:
LDN may support weight management by improving insulin sensitivity and reducing inflammation. It has been reported to aid in balancing hormones in conditions like polycystic ovary syndrome (PCOS).
6. Anti-Inflammatory Effects:
Chronic inflammation underlies many health issues, from cardiovascular disease to neurodegenerative disorders. LDN’s ability to reduce systemic inflammation makes it a valuable tool for overall health optimization.
Advantages of LDN Over Traditional Therapies
- • Low Risk of Side Effects: Unlike immunosuppressants or steroids, LDN is generally well-tolerated with minimal side effects, such as vivid dreams or temporary sleep disturbances.
- • Non-Addictive: Despite its origin as an opioid antagonist, LDN does not carry the risk of dependency.
- • Affordable: LDN is cost-effective compared to many pharmaceutical alternatives.
- • Versatile: Its wide-ranging applications make it a valuable addition to treatment protocols for various chronic conditions.
Is LDN Right for You?
Low-Dose Naltrexone is not a one-size-fits-all solution, but its safety profile and broad potential benefits make it worth discussing with your healthcare provider. Functional medicine practitioners are especially knowledgeable about how to integrate LDN into personalized treatment plans for autoimmune diseases and other chronic conditions and compounding pharmacies can formulate the dose that is right for you!
Low-Dose Naltrexone is revolutionizing the way we approach autoimmune diseases and chronic health issues. From reducing inflammation and pain to supporting mental health and enhancing immune function, LDN offers a versatile, affordable, and effective option for many patients. If you’re seeking a holistic and science-backed approach to managing your health, LDN may be the breakthrough you’ve been looking for.
Contact Martin's Wellness
Contact either of our pharmacy locations to inquire about LDN and our compounding services. Dripping Springs Pharmacy located at 100 Commons Road Dripping Springs, Texas 78620 (512) 858-7935 and Lamar Plaza Drug Store located at 1509 South Lamar Boulevard Austin, Texas 78704 (512) 442-6777.


Ruthie Harper, MD
Dr. Harper founded Ruthie Harper MD, her internationally recognized practice in Austin, Texas, in 1999. Since that time, she has consulted with more than 10,000 patients and offers the latest services and techniques in health and wellness in the medical division of her practice, as well as non-surgical rejuvenation and skincare in the cosmetic portion of her practice. Her ongoing success serving the health and beauty industries is based primarily on her innovative integration of research, nutritional science, advanced functional testing, and advanced aesthetics.